Critical role for the AIM2 inflammasome during acute CNS bacterial infection
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چکیده
منابع مشابه
Critical role for the NLRP3 inflammasome during acute lung injury.
The inflammasome is a key factor in innate immunity and senses soluble pathogen and danger-associated molecular patterns as well as biological crystals (urate, cholesterol, etc.), resulting in expression of IL-1β and IL-18. Using a standard model of acute lung injury (ALI) in mice featuring airway instillation of LPS, ALI was dependent on availability of NLRP3 as well as caspase-1, which are kn...
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Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms controlling activation of the AIM2 inflammasome in response to different cytosolic pathogens is unclear. Here, we show that the transcription factor IRF1 is the upstream molecule leading to AIM2 inflammasome activation during Francisella novicida infection, whereas engagement of the AIM2 inflammasom...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2014
ISSN: 0022-3042
DOI: 10.1111/jnc.12669